Agent Orange was the code name for a herbicide developed for the military, primarily for use in tropical climates. Although the genesis of the product goes back to the 1940's, serious testing for military applications did not begin until the early 1960's. The purpose of the product was to deny an enemy cover and concealment in dense terrain by defoliating trees and shrubbery where the enmy could hide. The product "Agent Orange" (a code name for the orange band that was used to mark the drums it was stored in, was principally effective against broad-leaf foliage, such as the dense jungle-like terrain found in Southeast Asia. The product was tested in Vietnam in the early 1960's, and brought into ever widening use during the height of the war (1967-68), though it's use was diminished and eventually discontinued in 1971. Agent Orange was a 50-50 mix of two chemicals, known conventionally as 2,4,D and 2,4,5,T. The combined product was mixed with kerosene or diesel fuel and dispersed by aircraft, vehicle, and hand spraying. An estimated 19 million gallons of Agent Orange were used in South Vietnam during the war. The earliest health concerns about Agent Orange were about the product's contamination with TCDD, or dioxin. TCDD is one of a family of dioxins, some found in nature, and are cousins of the dibenzofurans and pcb's. The TCDD found in Agent Orange is thought to be harmful to man. In laboratory tests on animals, TCDD has caused a wide variety of diseases, many of them fatal. TCDD is not found in nature, but rather is a man-made and always unwanted byproduct of the chemical manufacturing process. The Agent Orange used in Vietnam was later found to be extremely contaminated with TCDD.


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Agent Orange was the nickname given to a powerful herbicide and defoliant used by the U.S. military in its Herbicidal Warfare program during the Vietnam War. Agent Orange was used from 1961 to 1971, and was by far the most used of the so-called "rainbow herbicides" used during the program. Degradation of Agent Orange (as well as Agents Purple, Pink, and Green) released dioxins, which are alleged to have caused harm to the health of those exposed during the Vietnam War. Agents Blue and White were part of the same program but did not contain dioxins. Studies of populations highly exposed to dioxin indicate increased risk of various types of cancer and genetic defects; the effect of long term low level exposure has not been established. Since the 1980s, several lawsuits have been filed against the companies who produced Agent Orange, among them being Dow Chemical and Monsanto. U.S. veterans obtained $180 million in compensation in 1984, while Australian, Canadian and New Zealand veterans also obtained compensation in an out-of-court settlement the same year. In 1999, 20,000 South Koreans filed a lawsuit in Korea; in January 2006, the Korean Appeal Court ordered Monsanto and Dow to pay $62 million in compensation to about 6,800 people. However, no Vietnamese have obtained compensation, and on March 10, 2005 Judge Jack Weinstein of Brooklyn Federal Court dismissed the lawsuit filed by the Vietnamese victims of Agent Orange against the chemical companies that produced the defoliants/herbicides.Contents

Agent Orange, given its name from the 55 US gallon orange barrels it was shipped in, is a roughly 1:1 mixture of two phenoxy herbicides in ester form, 2,4-dichlorophenoxyacetic acid (2,4-D) and 2,4,5-trichlorophenoxyacetic acid (2,4,5-T). These herbicides were developed during the 1940s by independent teams in England and the United States for use in controlling broad-leaf plants. Phenoxy agents work by mimicking a plant growth hormone, indoleacetic acid (IAA). When sprayed on broad-leaf plants they induce rapid, uncontrolled growth, eventually killing them. When sprayed on crops such as wheat or corn, it selectively kills just the broad-leaf plants in the field - the weeds - leaving the crop relatively unaffected. First introduced in 1946, these herbicides were in widespread use in agriculture by the middle of the 1950s.

It was later learned that a dioxin, 2,3,7,8-tetrachlorodibenzo-para-dioxin (TCDD), is produced as a byproduct of the manufacture of 2,4,5-T, and was thus present in any of the herbicides that used it. The National Toxicology Program has classified TCDD to be a human carcinogen, frequently associated with soft-tissue sarcoma, Non-Hodgkin's lymphoma, Hodgkin's disease and chronic lymphocytic leukemia (CLL). 2,4,5-T has since been banned for use in the US and many other countries.

The herbicide 2,4-D does not contain dioxin, and it remains one of the most-used herbicides in the world today.

Diseases associated with dioxin exposure are chloracne, soft tissue sarcomas, Hodgkin's lymphoma, and non-Hodgkin's lymphoma. A link has also been found to diabetes, in a study by the Institute of Medicine. Diseases with limited evidence of an association with Agent Orange are respiratory cancers, prostate cancer, multiple myeloma, Porphyria cutanea tarda (a type of skin disease), acute and subacute transient peripheral neuropathy, spina bifida, Type 2 diabetes, and acute myelogenous leukemia found only in the second or third generation. Diseases with inadequate or insufficient evidence of an association are hepatobiliary cancers, nasal or nasophargyngeal cancers, bone cancer, female reproductive cancers, renal cancer, testicular cancer, leukemia, spontaneous abortion, birth defects, neonatal or infant death and stillbirths, low birth weight, childhood cancers, abnormal sperm parameters, cognitive neuropsychiatric disorders, ataxia, peripheral nervous system disorders, circulatory disorders, respiratory disorders, skin cancers, urinary and bladder cancer. Diseases with limited or suggestive evidence of no association are gastrointestinal tumors such as stomach cancer, pancreatic cancer, colon cancer, and rectal cancer, and brain tumors.


During the Vietnam War, the US instituted a massive herbicidal program that ran from 1961 through 1971. The aim of the program was twofold, one to destroy the "cover" provided by the jungle-like forest, and another to deny food to the enemy. First named Operation Trail Dust, then Operation Hades, it was finally renamed Operation Ranch Hand.

A variety of chemicals were tested or used operationally during this program. The primary broad-leaf herbicides sprayed during the "testing" phase of the program between 1962 and 1964 were Agent Orange, Agent Purple and Agent White. The chemicals themselves had no color; the names refer to colored stripes painted on the 55 gallon barrels to identify their contents. Much smaller amounts of other herbicides were also tested, including Agent Pink, Agent Green, Dinoxol, Trinoxol, Bromacil, Diquat, Tandex, Monuron, Diuron and Dalapon. Agent Blue was an unrelated herbicide based primarily on arsenic used to kill rice plants which were not susceptible to the phenoxy-based agents. A variety of Paraquat-related chemicals were apparently also tested in this role. For spraying, the various agents were mixed with kerosene or diesel fuel.

By 1964 the testing phase had ended, and Agent Orange was selected as the most effective agent for "territory denial". Operational use started in January 1965, increasing in breadth as logistical problems were solved. Most of Agent Orange sprayed during the program was delivered from modified US Air Force C-123K Provider aircraft under a program known as Operation Ranch Hand. Other delivery methods included helicopters, truck and hand spraying, notably for the areas directly around US bases. From 1968 on, an improved version known as "Orange II" or "Super Orange" was used as well.

Spraying reached its maximum during the most intense period of the war, between 1967 and 1968. After that the program "drew down", and ended in 1971. By this point an estimated 19 million gallons of herbicide had been sprayed on Vietnam, Cambodia, Thailand and Laos, somewhat more than half (55%) of that Agent Orange, between 1962 and 1971. Early estimates from 1974 had placed the amounts lower, between 12 and 14 million US gallons (45,000 and 53,000 m³). In total about 6 million acres (24,000 km²) were sprayed in Vietnam alone.


The New Jersey Agent Orange Commission

In 1980, New Jersey created the New Jersey Agent Orange Commission, the first state commission created to study its effects. The Commission's research project in association with Rutgers University was called "The Pointman Project". It was disbanded by governor Christine Todd Whitman in 1996.

During Pointman I, Commission researchers devised ways to determine small dioxin levels in blood. Prior to this, such levels could only be found in the adipose (fat) tissue. The project compared dioxin levels in a small group of Vietnam veterans who had been exposed to Agent Orange with a group of matched veterans who had not served in Vietnam. The results of this project were published in the Journal of the American Medical Association (JAMA) in 1988.(Vol. 259 No. 11, March 18, 1988).

The second phase of the project continued to examine and compare dioxin levels in various groups of Vietnam veterans including Army, Marines and brown water riverboat Navy personnel. In addition, the Commission was the only agency to examine such levels in women who served in Vietnam

The National Academy of Science 2003 report

An April 2003 report paid for by the National Academy of Sciences concluded that during the Vietnam War, 3,181 villages were sprayed directly with herbicides. Between 2.1 and 4.8 million people "would have been present during the spraying." Furthermore, many US citizens were given access to military records and Air Force operational folders previously not studied. The re-estimate made by the report places the volume of herbicides sprayed between 1962 and 1971 to a level 7,131,907 liters more than an uncorrected estimate published in 1974 and 9.4 million more liters than a 1974 corrected inventory. It was produced under contract for the Army by Diamond Shamrock, Dow, Hercules, Monsanto, T-H Agricultural & Nutrition, Thompson Chemicals, and Uniroyal.